周末NUMB3RS is a drama about FBI agent Don Eppes (Rob Morrow), who recruits his mathematical-genius brother, Charlie (David Krumholtz) to help the Bureau solve a wide range of challenging crimes in Los Angeles. The two brothers take on the most confounding criminal cases from a very distinctive perspective.Inspired by actual cases, the series depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions.A dedicated FBI agent, Don couldn't be more different from his younger brother, Charlie, a brilliant mathematician who, since he was little, has yearned to impress his big brother. As a seasoned investigator, Don deals in hard facts and evidence, whereas Charlie, a math professor at a California university, functions in a world of mathematical probability and equations.Now, despite their disparate approaches to life, Don and Charlie are able to combine their areas of expertise and solve some killer cases.